While DSM-V provides ways to classify psychopathologies, the National Institute of Mental Health (NIMH) has recognized that understanding the antecedents and progression of disorders, as well as stimulating research on new treatments, may require new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. The implementation of this strategy has been named the Research Domain Criteria Project (RDoC) . This talk will describe the background impetus for the RDoC project, the various domains of interest and the constructs included in those domains, and levels of analysis (from circuits to behavior) identified as critical research foci by work groups of scientists. However, domains and constructs of specific interest to behavioral analysis will provide the main focus. A brief overview of the knowledge gaps identified by NIMH and areas of high priority for research will be described, including explicit suggestions from NIMH for how these domains should be used to focus future research efforts by basic and clinician-scientists.