The session reviews the progress of behavior modification dealing with tobacco use prevention, and treatment during past decades. In comparison and adjusted with other techniques, behavioral techniques become the main treatment methods. Additionally, how to include new information related to nicotine addiction to health issues, such as gambling addictions have an extremely high correlation with smoking behavior will be also highlighted. This session, in contrast with past sessions, focuses from the present to future prevention and treatment needs of behavioral treatment with nicotine addictions. Case studies will be presented in conjunct withthe general discussion. The relationships between other drug use and tobacco use will be discussed. It is our experience that other drug use and smoking is as high as 95%. This prevalence has been long ignored by state funding sources. The reasons of why other drug users refused tobacco use will be reported. These include being afraid of weight gain, etc. The spouses who also smoke tend to reinforce their smoking behavior.